A prospective harmonized multicenter DTI study of cerebral white matter degeneration in ALS
Abstract Objective To evaluate progressive white matter (WM) degeneration in amyotrophic lateral sclerosis (ALS). Methods Sixty-six patients with ALS and 43 healthy controls were enrolled in a prospective, longitudinal, multicenter study in the Canadian ALS Neuroimaging Consortium (CALSNIC). Participants underwent a harmonized neuroimaging protocol across 4 centers that included diffusion tensor imaging (DTI) for […]